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Identification test for phenacetin|C10H13NO2

Date:6/12/2020
English Name: phenacetinum,phenacetin

[C10H13NO2=179.22]

This product is p-ethoxyacetanilide. The content of C10H13NO2 should not be less than 99.0%.

[character] the product is white, with glittering flake crystal or white crystalline powder; odorless, slightly bitter taste.

The product is dissolved in ethanol or chloroform, slightly soluble in boiling water, slightly soluble in ether, and very slightly dissolved in water.

Melting point the melting point of this product (Appendix page 13) is 134 ~ 137 ℃.


[identification] take 0.1g of this product, add 5ml hydrochloric acid, boil for about 2 minutes, add 10ml of water, cool down, filter, increase the filtrate, one drop of potassium chromate solution (0.01667mol / L) will show violet color, and then turn into ruby red.

[inspection] 0.6g of organochlorine was taken and put into a conical flask. 50mg nickel aluminum alloy, 5ml 90% ethanol, 10ml water and 2ml sodium hydroxide solution (1mol / L) were added, Put it in a water bath, heat and reflow for 10 minutes, cool down, filter it into a 50ml measuring bottle with chloride free filter paper, wash the conical flask and filter paper with water in several times, merge the washing solution into the measuring bottle, add water to dilute to the scale, shake well, separate 25ml, and check according to the law (Appendix page 35). In case of turbidity, compare with the control solution made of 25ml blank solution and 6ml standard sodium chloride solution 02%). For more information, please click here

For p-ethoxyaniline, take 0.3g, add 1ml ethanol, drop iodine solution (0.01mol/l) until slightly yellow, then add 0.05ml iodine solution (0.01mol/l) and 3ml newly boiled cold water. Heat it directly until it dissolves. Observe it immediately when it is hot. If the color is developed, it should not be deeper than the same volume of brown red No.4 standard colorimetric solution.

Take 0.5g of this product for easy carbonization, and check according to law. If it turns yellow, it shall not be deeper than orange yellow No.4 standard colorimetric solution of the same volume; if it is red, it shall not be deeper than brown red No.7 standard colorimetric solution of the same volume.

Loss on drying: take the product and dry it at 105 ℃ for 3 hours, and the weight loss shall not exceed 0.5%.

The residue on ignition shall not exceed 0.1%
[content determination] take about 0.35g of this product, accurately weigh it, put it into a conical flask, add 40 ml dilute hydrochloric acid, slowly heat and reflux for 1 hour, cool down, add 15ml water, and titrate with sodium nitrite solution (0.1mol/l) (but the sensitivity of galvanometer is changed to 10 < - 3 > A / grid) according to the permanent stop titration method (Appendix 53). Every 1ml of sodium nitrite solution (0.1mol/l) is equivalent to 17.92mg C10H13NO2.

[function and use] antipyretic and analgesic drugs. For fever, pain, etc.

[note] long term and large-scale use may cause cyanosis or kidney damage.

[storage] airtight storage.
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